Did You Know?

woman sitting at table silhouette

What You Eat AffectsHow You Feel >>

Did You Know?

strong man silhouette with 4 seasonal icons

You Deserve to FeelYour Best All Year Long>>

Did You Know?

profile of man writing silhouette

How to Talk the Talk>>

Facts & Figures

In the United States:

graphic of ~1 in 12 adults is affected by DEPRESSION graphic of ~1 in 12 adults is affected by DEPRESSION
graphic of 21 MILLION ADULTS had at least 1 MAJOR DEPRESSIVE EPISODE in 2021 graphic of 21 MILLION ADULTS had at least 1 MAJOR DEPRESSIVE EPISODE in 2021
graphic of ~13 MILLION ADULTS experience SEASONAL AFFECTIVE DISORDER (SAD) at a given time graphic of ~13 MILLION ADULTS experience SEASONAL AFFECTIVE DISORDER (SAD) at a given time
graphic of Depression is MOST COMMON among people aged 18 to 25 YEARS graphic of Depression is MOST COMMON among people aged 18 to 25 YEARS

What to do about depression

Seeking help from a healthcare professional is an important step in managing the symptoms of depression, which can cause many physical and mental health changes. Monitoring these changes and sharing them with a healthcare professional is an important step.

Depression is treatable:

80% to 90% of people with depression who seek treatment eventually respond well to treatment

graphic of 2 people with hands on shoulder of third person graphic of 2 people with hands on shoulder of third person

Managing Depression

Managing life through depression

It can sometimes be tough to see through feelings of depression and manage other important areas of your life, but they need attention too. It's also important to remember that it is possible to maintain healthy relationships while managing a mental illness. Below are a few key relationships that may be especially difficult to keep up with and a few ways to approach them.

Remember that keeping up with your treatment plan is integral to helping you manage other areas of your life—whether that's medication, talk therapy, or other forms of treatment recommended by your healthcare professional.

If you think you may be experiencing depression, it can be tough to know where to start. Here are a few steps that might help:

A diagnosis can only be made by a healthcare professional. Be sure to speak with a healthcare professional to determine how to appropriately manage your depression.

Learn about APLENZIN >>

Establishing routines
that work for you

Creating a routine may seem overwhelming at first, but once you find your rhythm it can help you feel more in control. Use 1 or 2 of these tips to get started, and speak to your healthcare professional for treatment options and advice.

establish-image establish-image

Use the discussion guide below to help support meaningful conversations about depression with family, friends, and/or a healthcare professional:

icon of person speaking

Talking to Family and Friends
About Your Depression

View Resource

Health & Wellness

Experiencing depression can feel like overcoming a hurdle, and sometimes the best approach can be to focus on your overall health and wellness to help improve how to tackle each day. Here are some tips and tricks that may help lighten your mental load.

graphic of figure walking

Go for a 10-minute walk to clear your mind

Close your eyes and refocus your breathing for 1 minute when feeling stressed

graphic of man looking up

Choose healthy foods
that could help you
feel better

View Resource
graphic of banana, fish, avocado

Plan a quick vacation to somewhere you find peaceful or enjoyable

graphic of palm trees graphic of palm trees
graphic of ear buds

Listen to music that makes you feel good—you can even make a trusty playlist for yourself

Find a calming activity like coloring, crocheting,
puzzles, etc

View Resource
graphic of crayon with scribble mark

Low stress vacation planning

A fun getaway can be a great way to give yourself something to look forward to and get yourself out of a funk, but the planning process can seem more overwhelming than it's worth (especially if you're planning for multiple people). Here are a few ways to make your vacation goals a reality with a little less stress.

Budget notebook icon

Set a budget to keep financial stress low. Staying within your budget will keep you focused on your trip and not add more worries to your plate

Bus icon

Choose a location you're excited about—that can mean a relaxing beach or a sightseeing adventure. Somewhere that brings you joy

Calculator icon

Keep a list of potential expenses and costs, including flights, hotels, car rentals, meals

  • One way to keep costs down is to choose a location that's closer to home. You'll be surprised by how many fun adventures are closer than you'd expect
Travel plan icon

If you can, reach out to a travel planner to help—some are compensated by the destination/hotel and free for the traveler

Destination icon

If you like to have a plan before heading somewhere, create a flexible itinerary. Leaving room for spontaneity and last minute changes can help manage how you will react. Sometimes how we mentally prepare can be the difference between having a good time or having a great time

Luggage icon

When it comes time to packing, give yourself time and don't rush. You may even want to make a list of items to bring or do an online search for suggested packing lists to help

Finish line flag icon

Keep your end goal in sight and remember you'll be somewhere you enjoy soon!

graphic of 2 figures sitting on a bench together
Join Real Talk

Real Talk Insights on Managing Depression is specifically designed to provide helpful tips and tools to anyone who may be interested in learning more about managing depression.

Common Questions

Answering common questions about depression and SAD

General questions, including treatment options, are based on information provided by the National Institute of Mental Health.

Treating Depression and SAD

APLENZIN FAQs

Additional Support

Use the following educational materials and links to increase your knowledge of depression and find additional support for managing symptoms:

National Alliance on Mental Illness (NAMI) HelpLine

Free, peer-support service of trained volunteers who can provide local referrals and come up with tangible next steps. Available Monday through Friday from 10 AM to 10 PM ET. Call 1-800-950-6264 or email helpline@nami.org.

National Suicide Prevention Lifeline

Free, confidential support available 24/7 for individuals in stress and for their loved ones. Call 1-800-273-8255 (English) or 1-888-628-9454 (en español).

Substance Abuse and Mental Health Services Administration (SAMHSA)

Free, confidential information and referral service offered 24/7 for individuals with mental health or substance abuse disorders and their loved ones. Call 1-800-662-4357.

INDICATION

APLENZIN® (bupropion hydrobromide extended-release tablets) is a prescription medicine used to treat adults with a certain type of depression called major depressive disorder, and for the prevention of autumn-winter seasonal depression (seasonal affective disorder).

IMPORTANT SAFETY INFORMATION

WARNING: CHANGES IN THINKING AND BEHAVIOR, DEPRESSION, AND SUICIDAL THOUGHTS OR ACTIONS

Suicidal Thoughts or Actions and Antidepressant Drugs

Antidepressants may increase the risk of suicidal thoughts or actions in some children, teenagers, or young adults within the first few months of treatment. Depression or other serious mental illnesses are the most important causes of suicidal thoughts and actions. People who have (or have a family history of) bipolar illness or suicidal thoughts or actions may have a particularly high risk. Pay close attention to any changes, especially sudden changes in mood, behaviors, thoughts, or feelings. Call your healthcare provider right away if symptoms such as anxiety, irritability, impulsivity, trouble sleeping, aggressive behavior or suicidal thoughts are new, worse or worry you. APLENZIN has not been evaluated for use in patients under the age of 18.

INDICATION

APLENZIN® (bupropion hydrobromide extended-release tablets) is a prescription medicine used to treat adults with a certain type of depression called major depressive disorder, and for the prevention of autumn-winter seasonal depression (seasonal affective disorder).

IMPORTANT SAFETY INFORMATION

WARNING: CHANGES IN THINKING AND BEHAVIOR, DEPRESSION, AND SUICIDAL THOUGHTS OR ACTIONS

Suicidal Thoughts or Actions and Antidepressant Drugs

Antidepressants may increase the risk of suicidal thoughts or actions in some children, teenagers, or young adults within the first few months of treatment. Depression or other serious mental illnesses are the most important causes of suicidal thoughts and actions. People who have (or have a family history of) bipolar illness or suicidal thoughts or actions may have a particularly high risk. Pay close attention to any changes, especially sudden changes in mood, behaviors, thoughts, or feelings. Call your healthcare provider right away if symptoms such as anxiety, irritability, impulsivity, trouble sleeping, aggressive behavior or suicidal thoughts are new, worse or worry you. APLENZIN has not been evaluated for use in patients under the age of 18.

Call your healthcare provider right away if you or your family member has any of the following symptoms, especially if they are new, worse, or worry you:

  • thoughts about suicide or dying
  • attempts to commit suicide
  • new or worse depression
  • new or worse anxiety
  • feeling very agitated or restless
  • panic attacks
  • trouble sleeping (insomnia)
  • new or worse irritability
  • acting aggressive, being angry, or violent
  • acting on dangerous impulses
  • an extreme increase in activity and talking (mania)
  • other unusual changes in behavior or mood

Although APLENZIN is not a treatment for quitting smoking, it contains the same active ingredient (bupropion) as ZYBAN, which is used to help patients quit smoking.

Some people have had serious side effects while taking bupropion to help them quit smoking, including:

New or worse mental health problems, such as changes in behavior or thinking, aggression, hostility, agitation, depression, or suicidal thoughts or actions. Some people had these symptoms when they began taking bupropion, and others developed them after several weeks of treatment, or after stopping bupropion. These symptoms happened more often in people who had a history of mental health problems before taking bupropion than in people without a history of mental health problems.

Stop taking APLENZIN and call your healthcare provider right away if you, your family, or caregiver notice any of these symptoms. Work with your healthcare provider to decide whether you should continue to take APLENZIN. In many people, these symptoms went away after stopping APLENZIN, but in some people, symptoms continued after stopping APLENZIN. It is important for you to follow-up with your healthcare provider until your symptoms go away.

Before taking APLENZIN, tell your healthcare provider if you have ever had depression or other mental health problems. You should also tell your healthcare provider about any symptoms you had during other times you tried to quit smoking, with or without bupropion.

What Other Important Information Should I Know About APLENZIN?

  • Seizures: There is a chance of having a seizure (convulsion, fit) with APLENZIN, especially in people with certain medical problems or who take certain medicines. Do not take any other medicines while you are taking APLENZIN unless your healthcare provider has said it is okay to take them. If you have a seizure while taking APLENZIN, stop taking the tablets and call your healthcare provider right away.
  • High blood pressure (hypertension): Some people get high blood pressure that can be severe while taking APLENZIN.
  • Manic episodes: Some people may have periods of mania while taking APLENZIN. If you have any of the following symptoms of mania, call your healthcare provider:
    • greatly increased energy
    • severe trouble sleeping
    • racing thoughts
    • reckless behavior
    • unusually grand ideas
    • excessive happiness or irritability
    • talking more or faster than usual
  • Unusual thoughts or behaviors: Some patients may have unusual thoughts or behaviors while taking APLENZIN, including delusions (e.g., believe you are someone else), hallucinations (seeing or hearing things that are not there), paranoia (feeling that people are against you), or feeling confused. If this happens to you, call your healthcare provider.
  • Visual problems: Some people are at risk of glaucoma which can present as: eye pain, changes in vision, or swelling and redness around the eye if they take APLENZIN. You should see an eye doctor to determine whether you are at risk prior to starting therapy.
  • Severe allergic reactions: Some patients have severe allergic reactions to APLENZIN. Stop taking APLENZIN and call your healthcare provider right away if you get a rash, itching, hives, fever, swollen lymph glands, painful sores in the mouth or around the eyes, swelling of the lips or tongue, chest pain, or have trouble breathing. These could be signs of a serious allergic reaction.

Do not take APLENZIN if you:

  • have or had a seizure disorder or epilepsy
  • have or had an eating disorder such as anorexia nervosa or bulimia
  • are taking any other medicines that contain bupropion, including WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, ZYBAN, or FORFIVO XL. Bupropion is the same active ingredient that is in APLENZIN
  • drink a lot of alcohol and abruptly stop drinking, or use medicines called sedatives (these make you sleepy), benzodiazepines, or anti-seizure medicines, and you stop using them all of a sudden
  • take a monoamine oxidase inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid
    • do not take an MAOI within 2 weeks of stopping APLENZIN unless directed to do so by your healthcare provider
    • do not start APLENZIN if you stopped taking an MAOI in the last 2 weeks unless directed to do so by your healthcare provider
  • are allergic to the active ingredient in APLENZIN, bupropion, or to any of the inactive ingredients

Although APLENZIN is not a treatment for quitting smoking, it contains the same active ingredient (bupropion) as ZYBAN, which is used to help patients quit smoking. Before taking APLENZIN, tell your healthcare provider if you have ever had depression, suicidal thoughts or actions, or other mental health problems or any symptoms you had during other times you tried to quit smoking with or without bupropion. Also, tell your healthcare provider about your other medical conditions, including if you:

  • have liver problems, especially cirrhosis of the liver
  • have kidney problems
  • have, or have had, an eating disorder such as anorexia nervosa or bulimia
  • have had a head injury
  • have had a seizure (convulsion, fit)
  • have a tumor in your nervous system (brain or spine)
  • have had a heart attack, heart problems, or high blood pressure
  • are a diabetic taking insulin or other medicines to control your blood sugar
  • drink alcohol
  • abuse prescription medicines or street drugs
  • are pregnant or plan to become pregnant. Talk to your healthcare provider about the risk to your unborn baby if you take APLENZIN during pregnancy, and about registering with the National Pregnancy Registry by calling 1-844-405-6185
  • are breastfeeding. APLENZIN passes into your milk in small amounts

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Many medicines increase your chances of having seizures or cause other serious side effects if you take them while you are using APLENZIN.

The most common side effects of APLENZIN include: trouble sleeping, stuffy nose, dry mouth, dizziness, feeling anxious, nausea, constipation, and joint aches.

Click here to read the Medication Guide carefully before you start using APLENZIN. If you have any questions about APLENZIN, ask your healthcare provider or pharmacist.

Click here for full Prescribing Information, including Medication Guide and Boxed Warning regarding suicidal thoughts and actions.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You may also contact Bausch Health Customer Service at 1-800-321-4576.